Crum et al used data from the National Epidemiologic Survey on Alcohol and Related Conditions to evaluate the hypothesis that alcohol self-medication of mood symptoms increases the probability of subsequent onset and the persistence or chronicity of alcohol dependence.

Seo and colleagues aimed to identify neural correlates associated with alcohol craving and relapse outcomes in 45 treatment-engaged, 4- to 8-week–abstinent alcohol-dependent patients, and compare brain responses of 30 demographically matched alcohol-dependent patients and 30 healthy control subjects during stress, alcohol, and neutral-relaxing cues. Volkow and Baler provide a related editorial.

Decety et al evaluated the differences in patterns of neural activity in 80 incarcerated individuals with psychopathy and incarcerated persons serving as controls during the perception of empathy-eliciting stimuli depicting other people experiencing pain.

Beucke et al determined regions of abnormal degree connectivity in 46 patients with obsessive-compulsive disorder (OCD) to investigate whether connectivity measures are affected by antidepressant medication in this population.

Kendler et al determine the structure of genetic and environmental risk factors for the 9 DSM-IV symptomatic MD criteria.