Oct 14, 2014

Conserved Domain Database (CDD) version 3.12 is now available with 1526 new or updated NCBI-curated domains and 49,955 total domain models from CDD’s database providers: Pfam, SMART, COG, TIGRFAMs, Protein Clusters, and the NCBI in-house curation project.

Oct 10, 2014

NCBI has updated its assembly alignment software (now version 1.7), which generates the alignments used for Remap, NCBI's coordinate remapping service. The improvements include: better handling of alternate loci and fix patches, improved alignments in regions of copy number variation, better recognition of sequence regions that are unaltered between two versions of a WGS assembly, incorporation of fixes to BLAST including bugs affecting alignments around regions with multiple mismatches and indels, and assorted other quality improvements.

Oct 9, 2014

The latest blog post on the NCBI Insights blog continues the discussion of GRCh38. This time, the blog post focuses on how GRCh38 improved gene annotation.