SLC4A8

Solute carrier family 4, sodium bicarbonate cotransporter, member 8
Identifiers
Symbols	SLC4A8 ; NBC3; NDCBE
External IDs	OMIM: 605024 MGI: 1928745 HomoloGene: 68419 IUPHAR: 912 GeneCards: SLC4A8 Gene
Gene ontology Molecular function • inorganic anion exchanger activity Cellular component • plasma membrane • integral component of membrane Biological process • ion transport • sodium ion transport • bicarbonate transport • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9498	59033
Ensembl	ENSG00000050438	ENSMUSG00000023032
UniProt	Q2Y0W8	Q8JZR6
RefSeq (mRNA)	NM_001039960	NM_001033218
RefSeq (protein)	NP_001035049	NP_067505
Location (UCSC)	Chr 12: 51.79 – 51.9 Mb	Chr 15: 100.76 – 100.82 Mb
PubMed search	[1]	[2]

Electroneutral sodium bicarbonate exchanger 1 is a protein that in humans is encoded by the SLC4A8 gene.

See also

• Solute carrier family
• cotransporter

Interactions

SLC4A8 has been shown to interact with Sodium-hydrogen antiporter 3 regulator 1 and Cystic fibrosis transmembrane conductance regulator.

Further reading

• Soleimani M (2002). "Na⁺:HCO₃⁻ cs (NBC): expression and regulation in the kidney". J. Nephrol. 15 Suppl 5: S32–40. PMID 12027220. 
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. 
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Loiselle FB, Morgan PE, Alvarez BV, Casey JR (2004). "Regulation of the human NBC3 Na⁺/HCO₃⁻ cotransporter by carbonic anhydrase II and PKA". Am. J. Physiol., Cell Physiol. 286 (6): C1423–33. doi:10.1152/ajpcell.00382.2003. PMID 14736710. 
• Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S et al. (2003). "The COOH termini of NBC3 and the 56-kDa H⁺-ATPase subunit are PDZ motifs involved in their interaction". Am. J. Physiol., Cell Physiol. 284 (3): C667–73. doi:10.1152/ajpcell.00225.2002. PMID 12444018. 
• Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A et al. (2003). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO₃⁻ salvage transporter human Na⁺-HCO₃⁻ cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779. 
• Gresz V, Kwon TH, Vorum H, Zelles T, Kurtz I, Steward MC et al. (2002). "Immunolocalization of electroneutral Na⁺-HCO cotransporters in human and rat salivary glands". Am. J. Physiol. Gastrointest. Liver Physiol. 283 (2): G473–80. doi:10.1152/ajpgi.00421.2001. PMID 12121896. 
• Amlal H, Burnham CE, Soleimani M (1999). "Characterization of Na⁺/HCO₃⁻ cotransporter isoform NBC-3". Am. J. Physiol. 276 (6 Pt 2): F903–13. PMID 10362779. 
• Pushkin A, Abuladze N, Lee I, Newman D, Hwang J, Kurtz I (1999). "Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family". J. Biol. Chem. 274 (23): 16569–75. doi:10.1074/jbc.274.23.16569. PMID 10347222. 
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.