Projects

A Phase 3 trial of the RTS,S/AS01E malaria vaccine is underway in multiple African trial sites. A first interim analysis has shown a vaccine efficacy f 55.8% (95% CI 50.6-60.4) against clinical malaria and 47.3% (95% CI 22.4-64.2) against severe…

The ultimate goal of the program of work will be to develop the evidence base for the effect of reproductive health and family planning services on fertility, child and maternal health, children’s education, female labor supply and household poverty. This…

The proposed study is a phase III, multicenter, controlled, double blind, randomized clinical trial in Thailand to compare the efficacy, safety and tolerance of each of two drugs, tenofovir and lamivudine, versus placebo, given to hepatitis B (HB) chronically infected…

Botswana has been a leader in galvanizing an effective regional and global response to the epidemic. Despite being one of the countries hardest hit by HIV/AIDS, Botswana was one of the first countries in Africa to provide free universal public…

The South African Executive Leadership Program in Health (SAELPH) is a partnership among the University of Pretoria (UP), the Harvard School of Public Health (HSPH), and the University of Fort Hare (UFH) in collaboration with the South African National Department…

Using the Nurses’ Health Study II, we aim to evaluate PCBs, DDE, HCB, and PFCs in relation to 1) subsequent weight gain, 2) development of newly diagnosed type 2 diabetes, and 3) markers of insulin resistance/glucose metabolism abnormalities, including fasting…

Seafood is a main source of human exposure to environmental pollutants, such as methyl mercury and lipophilic contaminants, including polychlorinated biphenyls (PCBs). In addition perfluorinated compounds (PFCs) biomagnify in ocean food chains, with the highest concentrations in marine mammals at…

To assess the role of environmental chemicals in the etiology of type 2 diabetes development, a birth cohort of 1022 subjects born in 1986-1987 will be examined in the Faroe Islands, where an unusually wide range of exposures to environmental…

 Project Summary/Abstract (Description) Preterm delivery (PTD) continues to be one of the most significant unsolved problems of public health and perinatology. There is increasing evidence that PTD is a complex cluster of problems with a set of overlapping factors and…

Since South Africa began its national rollout of antiretroviral therapy (ART) for HIV in 2004, adult life expectancy has increased dramatically. However, in the general population in-depth knowledge about ART and its impact on survival is incomplete. We will implement…

In order to advance our understanding of the health status of the Hispanic population of Mexican origin in the U.S., it is necessary to explore the health status of the sending population. The aim of the project is twofold. First,…

The research will develop a protocol for study to be conducted in a poor urban African setting where total fertility is high, contraceptive prevalence is low, and access to family planning services is costly.

The goals of this project are to build sustainable capacity for research on health and its social determinants in low- and middle-income countries, using methods in epidemiology and demography, health economics, environmental health, evaluation sciences. The Harvard Center for Population…

This project aims to support Management and Development for Health to implement the SHAPE Project (Strengthening HIV/AIDS Program Efficiencies in Dar es Salaam) objectives by providing Technical Assistance in areas of quality improvement, nutritional assessment and interventions, and finance and…

The goal of this project is to develop a robust in vitro culture system for the human malaria parasite, Plasmoduim vivax, that will facilitate biological studies and support the design of health interventions.

H3ABioNet aims to create a sustainable African Bioinformatics Network to support H3Africa researchers through the development of bioinformatics capacity on the continent. Specifically, it aims to: 1) engage with the H3Africa Consortium, providing a framework for integration and communication amongst…

This project is to evaluate the impact and cost effectiveness of combination HIV prevention interventions on population-level HIV incidence in Botswana, a country with a severe generalized HIV epidemic.

Over time Americans, especially women, have experienced high demands in terms of full time work often with high family demands, coupled with low formal support ( social protection policies) or informal support from other family members. The aims of this…

This research focuses on analyzing the HIV virus strain in southern Africa, as distinct from HIV strain that currently dominates is US and Europe. The study combines that analysis with an analysis of the genetics of the people in the…