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Possibly the best-known 12-bit CPU is the PDP-8 and its relatives, such as Intersil 6100 microprocessor produced in various incarnations from August 1963 to mid-1990. Many analog to digital converters (ADCs) have a 12-bit resolution. Some PIC microcontrollers use a 12-bit word size.
12 binary digits have 4096 (10000 octal, 1000 hexadecimal) distinct combinations. Hence, a microprocessor with 12-bit memory addresses can directly access 4096 words (4 Kw) of word-addressable memory. At a time when six-bit character codes were common a 12-bit word, which could hold two characters, was a convenient size.