Research Fellow
Department of Genetics and Complex Diseases
Education:
Ph.D. Biochemistry 2014, State University of New York at Buffalo, Buffalo NY
B.S. Biomedical Sciences 2009, State University of New York at Buffalo, Buffalo NY
Publications:
McCarthy RC and Kosman DJ (2014). Iron transport across the blood-brain barrier; development, neurovascular regulation and cerebral amyloid angiopathy. Cell Mol Life Sci. (Paper in press).
McCarthy RC and Kosman DJ (2014). Activation of C6 glioblastoma cell ceruloplasmin expression by neighboring brain endothelia-derived interleukins in an in vitro blood-brain barrier model system. Cell Commun Signal 12(1):65.
McCarthy RC, Park Yun-hee, Kosman DJ (2014). sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin. EMBO Rep 15(7):809-15.
McCarthy RC and Kosman DJ (2014). Glial cell ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells. PLoS ONE 9(2): e89003.
McCarthy RC and Kosman DJ (2013). Ferroportin and exocytoplasmic ferroxidase activity are required for brain microvascular endothelial cell iron efflux. J Biol Chem 288, 17932-17940.
McCarthy RC and Kosman DJ (2012). Mechanistic analysis of iron accumulation by endothelial cells of the BBB. Biometals 25(4):665-75.
Ziegler L, Turzulli A, Gaur R, McCarthy R, Kosman DJ (2011). Functional characterization of the ferroxidase, permease high-affinity iron transport complex from Candida albicans. Mol Microbiol 81(2):473-85.
E-mail:
rmccarth@hsph.harvard.edu