Sarah Otto

@sarperotto

Evolutionary biologist; Prof at UBC; enthusiast of modelling and scientific discovery

Joined May 2014
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  1. Retweeted
    Mar 2

    Looking for a British Columbia resident interested in late spring/early summer employment doing stickleback field work on Vancouver Island, as the pandemic continues to restrict our ability to to field work travel. Please rt

    9 replies 107 retweets 106 likes
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  2. Retweeted
    Feb 25

    It is really disturbing to see the pundits accusing and other scientist of "undermining confidence" in BC's response to COVID. It's not just one account - it's several and the messaging seems coordinated. The point of science isn't to toe a party line.

    6 replies 51 retweets 193 likes
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  3. Retweeted
    Feb 25

    We are extremely lucky to have here in BC, who is a total powerhouse doing world-class research and finds time to build models tuned to BC and Canada data advising BC and PHAC. We need more not fewer scientists bringing their deep expertise to policy questions.

    It is really disturbing to see the pundits accusing and other scientist of "undermining confidence" in BC's response to COVID. It's not just one account - it's several and the messaging seems coordinated. The point of science isn't to toe a party line.
    2 replies 28 retweets 100 likes
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  4. Retweeted
    Feb 25

    Understanding and avoiding misplaced efforts in by

    34 retweets 64 likes
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  5. Retweeted
    Feb 23

    Great work looking at impact of different vaccine strategies on mortality and morbidity in the BC context. It shows that after immunizing 80+ year olds it’s best to switch to essential workers first rather than go down the age ladder.

    Preprint: Vaccinating essential workers (or "high-contact adults"!) is likely to be much better in BC, Canada and similar places Paper: Github:
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    1 reply 25 retweets 58 likes
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  6. Feb 24

    Correct, nor B.1.525, which doesn’t have N501Y, which is what is targeted here in BC. Would catch B.1.1.7, P1, B.1.351. Unclear still which have a strong transmission advantage as B.1.1.7??

    Replying to @sarperotto
    I don’t think it would have found Q677H/P variants but these aren’t clearly of concern, yet
    1 like
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  7. Feb 24

    I haven’t heard about WGS finding VOC that the SNP assay hasn’t...but I don’t know the details

    Replying to @rdumont99 @sarperotto
    What about the false-negative rate? Do they have a way to investigate that?
    1 reply
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  8. Feb 23

    At the moment, we’re just getting numbers in the news updates (no sample dates, locations, travel history, etc.). I hope more VOC data will be made available for downloading so we can better model COVID case numbers!

    Replying to @sarperotto
    Is the typing information posted somewhere we can look at it?
    4 retweets 15 likes
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  9. Feb 23

    Great to hear that BC is now typing 70% of cases for Variants of Concern and able to get that information back out one day later! Plus aim to ramp this up (100% typing of tested cases). This is what we need to isolate VOC & prevent them from establishing.

    3 replies 4 retweets 36 likes
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  10. Retweeted
    Feb 20

    Une séquence génétique ne gagne du sens qu'en la comparant à d'autres. Il existe pour cela des plateformes internationales de partage. Garder pendant des semaines/mois des séquences de SARS-CoV-2 sur ses disques durs sans les partager est contre-productif pour tout le monde, 🇫🇷.

    illustration, arbre phylogénétique SARS-CoV-2, nextstrain.org
    2 replies 30 retweets 68 likes
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  11. Retweeted
    Feb 18

    New research paper by researchers and Gwich'in elders in working together to study łuk dagaii (broad whitefish, Coregonus nasus), subsistence harvest, & climate change in Settlement Area, Yukon:

    1 reply 10 retweets 18 likes
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  12. Feb 18

    Vaccines appear to lower transmission rates: the early calculations from (Moderna) are broadly consistent with latest analysis of data from Israel (Pfizer). Major reduction (89%) in infection, not just symptomatic cases!

    Everyone wants to know whether vaccines prevent transmission: worked hard and found an answer. I hope it's the right one! Thanks to and for talking to me.
    4 replies 23 retweets 79 likes
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  13. Retweeted
    Feb 17

    We found a sexual conflict gene!! Alleles of Puf60b have opposing effects on survival in wild guppies. Genotype frequencies and survival (females in red, males in blue, expected in grey) are mind-blowing! Amazing work led by just out

    , , and
    9 replies 81 retweets 292 likes
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  14. Retweeted
    Feb 18

    America is ignoring the coronavirus variants at its own peril

    2 replies 24 retweets 43 likes
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  15. Retweeted
    Feb 17

    Do you find yourself in need of aligning 500k very similar sequences on a laptop? We (mostly ) developed a reference aligner 'nextalign' that aligns 500k sequences in 30min using 8 cores and just a few GB of RAM.

    3 replies 57 retweets 238 likes
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  16. Retweeted
    Feb 11

    We’re thrilled to announce the launch of Supporting Diverse Voices: Book Proposal Development Grants, an endeavor built on the recognition that mentorship networks and other intellectual lineages have often been amplified to the exclusion of already underrepresented voices. 1/5

    6 replies 214 retweets 306 likes
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  17. Feb 12

    So grateful to have these two receive vaccines today (Moderna). 😘

    2 retweets 218 likes
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  18. Feb 12

    Additionally, one case of a new Variant-of-(Maybe)Concern was found in BC, B.1.525, which has been flagged as having a similar set of genetic mutations. There is no clear evidence about whether it transmits more, but scientists are keeping an eye out.

    1 reply 3 likes
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  19. Feb 12

    On the positive side: Dr. Bonnie Henry reported that a point prevalence test in BC found only 3 variants of concern (2 B.1.1.7 & 1 B.1.351) out of all 3099 positive samples from Jan30-Feb5, indicating that we do not yet have establishment and exponential growth in BC.

    1 reply 1 retweet 5 likes
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