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shape-analysis

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An open-source, free comprehensive software that will allow biomedical scientists to precisely locate shape changes in their imaging studies. This software called Slicer Shape AnaLysis Toolbox (SlicerSALT), will enhance the intuitiveness and ease of use for such studies, as well as allow researchers to find shape changes with higher statistical power. Altogether this constitutes a crucial resource for the imaging field that will enable many and important new findings in biomedical imaging studies.

  • Updated Aug 4, 2020
  • Python

Morphological categorization of neurons in order to explore their functional features has drawn significant attention over past few decades. The enormous complexity in the structure of neurons poses a real challenge in the identification and analysis of similar and dissimilar neuronal cells. Existing methodologies often carry out strutural and geometrical simplifications, which substantially changes the morphological statistics. Using digitally-reconstructed neurons, we extend the work of Path2Path as ElasticP2P, which seamlessly integrates the graph-theoretic and differential-geometric frameworks. By decomposing a neuron into a set of paths, we derive graph metrics, which are path concurrence and path hierarchy. Next, we model each path as an elastic string to compute the geodesic distance between the paths of a pair of neurons. Later, we formulate the problem of finding the distance between two neurons as a path assignment problem with a cost function combining the graph metrics and the geodesic deformation of paths.

  • Updated Mar 21, 2018
  • MATLAB

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