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Single (i) Cell R package (iCellR) is an interactive R package to work with high-throughput single cell sequencing technologies (i.e scRNA-seq, scVDJ-seq, scATAC-seq, CITE-Seq and Spatial Transcriptomics (ST)).

  • Updated Jun 9, 2021
  • R

A fast, accurate, and modularized dimensionality reduction approach based on diffusion harmonics and graph layouts. Escalates to millions of samples on a personal laptop. Adds high-dimensional big data intrinsic structure to your clustering and data visualization workflow.

  • Updated Apr 4, 2021
  • Python
davisidarta
davisidarta commented May 6, 2021

Hi! This is fantastic work, congratulations!

I'm, however, saddened by the somewhat hard-coded kNN graph computation, based solely on PCA, which can be misleading if data does not necessarily lie in a series of linear subspaces. A huge deal of work has been done lately on dimensional reduction, and thus restricting the kNN graphs to PCA is an important limitation. Is there any way to compute th

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