Conserved Differentially Methylated Elements from One Generation to the Next: Inheritance versus Randomness
The methylInheritance package implements a permutation analysis, based on Monte Carlo sampling, for testing the hypothesis that the number of conserved differentially methylated elements, between several generations, is associated to an effect inherited from a treatment and that stochastic effect can be dismissed.
Citing
If you use this package for a publication, we would ask you to cite the following:
Pascal Belleau, Astrid Deschênes, Marie-Pier Scott-Boyer, Romain Lambrot, Mathieu Dalvai, Sarah Kimmins, Janice Bailey, Arnaud Droit; Inferring and modeling inheritance of differentially methylated changes across multiple generations, Nucleic Acids Research, Volume 46, Issue 14, 21 August 2018, Pages e85. DOI: https://doi.org/10.1093/nar/gky362
Bioconductor Package
methylInheritance is now an official package of Bioconductor. The current release can be directly downloaded from their website: Current release
Description of Package Functionality
The vignette of the methylInheritance package, which is a document that provides a task-oriented description of the package functionality, is available on Bioconductor website: methylInheritance vignette
Authors
Astrid Deschênes, Pascal Belleau and Arnaud Droit.
License
This package and the underlying methylInheritance code are distributed under the Artistic license 2.0. You are free to use and redistribute this software.
For more information on Artistic 2.0 License see http://opensource.org/licenses/Artistic-2.0
Bugs/Feature requests
If you have any bugs or feature requests, let us know.
Thanks!